Jump to content


Photo

Add duration of patch application in Transdermal Modelling


  • Please log in to reply
5 replies to this topic

#1 harishkaushik

harishkaushik

    Newbie

  • Members
  • Pip
  • 7 posts

Posted 26 April 2021 - 05:26 PM

Hello All,
 
Iam trying to develop Donepezil, TDS patch modelling,
 
When i input dose (actual dose is 175mg/50cm2 area) as 175mg at T=0 then data is fitting well, but the issue is how do I provide the input that patch was applied for 72hr duration post that patch was removed in naive pooled modelling
 
also what should i write in the above PML code, if i want to simulate the 175mg/50cm2 patch applied for 24 hr duration instead of 72hr, how should i do it?
 
 
 
i have developed the below PML code
 
test(){
deriv(A1 = - (VMax * C3 / (C3 + Km)) + (K23 * C2))
urinecpt(A0 = (VMax * C3 / (C3 + Km)))
deriv(Aa2 = - (Aa2 * K12))
deriv(A2 = (Aa2 * K12)- (K23 * C2))
C3 = A1 / V3
error(CEps = 1)
observe(CObs = C3 + CEps * sqrt(1 + (C3)^2 * (CMultStdev/sigma())^2))
dosepoint(Aa2, tlag = (Tlag), idosevar = Aa2Dose, infdosevar = Aa2InfDose, infratevar = Aa2InfRate)
C2 = A2 / V2
stparm(V3 = tvV3)
stparm(VMax = tvVMax)
stparm(Km = tvKm)
stparm(V2 = tvV2)
stparm(K12 = tvK12)
stparm(K23 = tvK23)
stparm(Tlag = tvTlag)
stparm(CMultStdev = tvCMultStdev)
fixef(tvV3 = c(, 141111, ))
fixef(tvVMax = c(, 1760000, ))
fixef(tvKm = c(, 24, ))
fixef(tvV2 = c(, 141, ))
fixef(tvK12 = c(, 0.027, ))
fixef(tvK23 = c(, 1.9, ))
fixef(tvTlag = c(, 4, ))
fixef(tvCMultStdev = c(, 1, ))
}
 
 
Attaching data for help
 
It will be of great help if any one can help
 
Regards
Harish

Attached Files


Edited by harishkaushik, 26 April 2021 - 05:33 PM.


#2 smouksassi1

smouksassi1

    Advanced Member

  • Members
  • PipPipPip
  • 179 posts
  • LocationMontreal

Posted 27 April 2021 - 07:26 AM

you can specify the patch duration in your dataset or as a modeled duration it depends what you want to do and how

 

here is when you let it be read from the data 

 

 

you will also need to take into account the speed (rate) as patches are saturated and will not deliver all the dose 



#3 harishkaushik

harishkaushik

    Newbie

  • Members
  • Pip
  • 7 posts

Posted 27 April 2021 - 07:29 AM

you can specify the patch duration in your dataset or as a modeled duration it depends what you want to do and how

 

here is when you let it be read from the data 

 

 

you will also need to take into account the speed (rate) as patches are saturated and will not deliver all the dose 

Sorry Smoukassi,

Couldnt understand what you imply, i wanted to first fit the data obtained after 72hr patch application and then using the estimates simulate the data after 24hr patch application (let the rate of delivery of drug from the patch be same)

 

It would be helpful, if you could help further

 

Regards

Harish



#4 smouksassi1

smouksassi1

    Advanced Member

  • Members
  • PipPipPip
  • 179 posts
  • LocationMontreal

Posted 27 April 2021 - 07:39 AM

Hi Harish,

I cannot solve your problem because I don't know all the details

 

see the attached and then you let me know what you need

Attached Files



#5 harishkaushik

harishkaushik

    Newbie

  • Members
  • Pip
  • 7 posts

Posted 27 April 2021 - 07:50 AM

Hi Harish,

I cannot solve your problem because I don't know all the details

 

see the attached and then you let me know what you need

Hello Smoukassi,

Thanks for sharing the project,

objective was the data which i shared earlier was obtained after 72hr patch application and the model code was shared earlier

post fitting the data with code, wanted to simulate the 24 hr patch data (decreasing the duration of patch application from 72hr to 24 hr and see how the data looks like)

Hope its clear now

 

Regards

Harish



#6 smouksassi1

smouksassi1

    Advanced Member

  • Members
  • PipPipPip
  • 179 posts
  • LocationMontreal

Posted 27 April 2021 - 07:55 AM

see how I did that in the project you need to tell the software the total amount of dose delivered within the 24 hours and then if it is the same rate total dose delivered will be 1/3 of the dose delivered in 72 h

did you open the project and saw the sims for 72 and 24 h ?






0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users