Hello All,
Iam trying to develop Donepezil, TDS patch modelling,
When i input dose (actual dose is 175mg/50cm2 area) as 175mg at T=0 then data is fitting well, but the issue is how do I provide the input that patch was applied for 72hr duration post that patch was removed in naive pooled modelling
also what should i write in the above PML code, if i want to simulate the 175mg/50cm2 patch applied for 24 hr duration instead of 72hr, how should i do it?
i have developed the below PML code
test(){
deriv(A1 = - (VMax * C3 / (C3 + Km)) + (K23 * C2))
urinecpt(A0 = (VMax * C3 / (C3 + Km)))
deriv(Aa2 = - (Aa2 * K12))
deriv(A2 = (Aa2 * K12)- (K23 * C2))
C3 = A1 / V3
error(CEps = 1)
observe(CObs = C3 + CEps * sqrt(1 + (C3)^2 * (CMultStdev/sigma())^2))
dosepoint(Aa2, tlag = (Tlag), idosevar = Aa2Dose, infdosevar = Aa2InfDose, infratevar = Aa2InfRate)
C2 = A2 / V2
stparm(V3 = tvV3)
stparm(VMax = tvVMax)
stparm(Km = tvKm)
stparm(V2 = tvV2)
stparm(K12 = tvK12)
stparm(K23 = tvK23)
stparm(Tlag = tvTlag)
stparm(CMultStdev = tvCMultStdev)
fixef(tvV3 = c(, 141111, ))
fixef(tvVMax = c(, 1760000, ))
fixef(tvKm = c(, 24, ))
fixef(tvV2 = c(, 141, ))
fixef(tvK12 = c(, 0.027, ))
fixef(tvK23 = c(, 1.9, ))
fixef(tvTlag = c(, 4, ))
fixef(tvCMultStdev = c(, 1, ))
}
Attaching data for help
It will be of great help if any one can help
Regards
Harish
Attached Files
Edited by harishkaushik, 26 April 2021 - 05:33 PM.