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xenograft tumor growth/kill modeling


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#1 yongcertara

yongcertara

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Posted 02 September 2021 - 01:35 PM

I am a bignner level user modeling tumor growth and kill in xenograft mice. The simplest differential equations are dT/dt = Kng*T for exponential growth and dT/dt = Kng*T(1-T/Tss).

T: Tumor size; Kng: net growth rate; Tss: maximum tumor sustainable tumor size.

 

My questions are : how to get initial estimate for parameters, Kng and Tss.

Mice were euthernized before tumor growth reachs pleatau, so no empirial data of Tss.

 

Thanks 



#2 Simon Davis

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Posted 03 September 2021 - 09:42 AM

if your initial estimate is within an order magnitude then you should be OK, if you think you have OK values for everything else, try using the inital estimate tool/tab to 'dial' them in.  Practically speaking i am guessing on a mouse a tumour volume of 2 cubic cm might a reasoanble max size to start with?






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