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PK simulation in Phoenix

modeling simulation PK/PD

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#1 Ygsla

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Posted 21 October 2021 - 10:57 AM

Can we do PK modeling or simulation using Phoenix winNonlin/nlme module? If yes can someone elaborate process. I need to build model using observed PK data linked with git pH value and predict data for future batch w.r.t. pH effect.



#2 cradhakr

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Posted 21 October 2021 - 11:12 AM

Hi Ygsla,

 

Yes we could do PK modeling using Phoenix NLME or with RsNLME (R Speaks NLME). I have attached a youtube link which takes throught the process of simulation using Phoenix. Please let us know if you need furhter assistance.

 

 

Also, if you are new to Modeling I would recommend you to consider our online course at Certara University or PML School at Certara Forum.

 

Thanks

Mouli


Edited by cradhakr, 21 October 2021 - 11:20 AM.


#3 amashehri

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Posted 24 October 2021 - 02:08 AM

Hi Cradhakr 

 

Can you please reattached the link to YouTube video. 

 

Thanks 



#4 Ygsla

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Posted 25 October 2021 - 05:00 AM

cradhakr, on 21 Oct 2021 - 4:42 PM, said:

Hi Ygsla,
 
Yes we could do PK modeling using Phoenix NLME or with RsNLME (R Speaks NLME). I have attached a youtube link which takes throught the process of simulation using Phoenix. Please let us know if you need furhter assistance.
 

 
Also, if you are new to Modeling I would recommend you to consider our online course at Certara University or PML School at Certara Forum.
 
Thanks
Mouli
 
 
Hi Mouli,
 
Thank you for prompt reply !!
 
I have two different formulation PK data and git pH data of same formulation, and I want to build model to see impact of pH on PK of two formulation and accordingly with built model want to predict impact on other formulation. Request you to pls elaborate the process like how do I start with Phoenix NLME.
 
Regards,

 


Edited by Ygsla, 25 October 2021 - 05:08 AM.


#5 cradhakr

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Posted 25 October 2021 - 07:19 AM

Hi Cradhakr 

 

Can you please reattached the link to YouTube video. 

 

Thanks 

Hi Amashehri, 

 

Please find attached the linke for the simulation.

 

https://www.youtube....h?v=daSpOq1mczc.

 

Thanks

Mouli


Edited by cradhakr, 25 October 2021 - 07:20 AM.


#6 cradhakr

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Posted 26 October 2021 - 06:26 AM

 

Hi,

 

Since you have the pH data - you could see this as a covariate effect and see if this affects the PK of your formulation. Also, I would recommend you to look at our PML School (Forum & our youtube channel). 

If you need further assistance please let  me know.

 

Thanks

Mouli






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