Is there any provision to determine Reference scaled average bioequivalence for Highly variable drugs?
In which, We are interested to calculate 95% Upper confidence bound. The parameter in which we are interested to estimate is critbound. How we can use WinNonlin (version 188.8.131.5214) to estimate it? Suggest if any additional module require for this.
We went through the AAPS Poster presentation,2013
Note: I have an active license access towards Basic WinNonlin. (v 184.108.40.20614)
Kindly support by providing any relevant examples, Templates, Workflow etc.
Awaiting for your revert.