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zero-order dissolution

dissolution zero-order IVIVC

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#1 Tkin

Tkin

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Posted 24 November 2021 - 03:05 PM

If dissolution data has a linear correlation (cumulative mass vs time) that is indicative of zero-order release, is it appropriate to fit a sigmoidal dissolution model?

 

The IVIVC toolkit in Phoenix allows only 4 choices for dissolution profiles: Hill, Weibull, Double Weibull and Markoid-Banakar.

 

If a sigmoid model is inappropriate, then how do we move forward to correlation within phoenix without choosing a sigmoid fit?

 

I am currently stumped on this issue. Could it be that the toolkit is wholly inappropriate for zero-order release rates?



#2 Simon Davis

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Posted 24 November 2021 - 03:20 PM

If a model is not required then check the box "use raw data".  Simon.







Also tagged with one or more of these keywords: dissolution, zero-order, IVIVC

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