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[Emily Colby]

Here is the PML model text for a target mediated drug disposition model.

 

test(){

    DOSE = 2.7

    deriv(CMAB = -CMAB*KelmAb - Kon*CMAB*(CAg - CComplex) + Koff*CComplex)

    error(CMABEps=1)

    observe(CMABObs = CMAB+CMABEps)

    deriv(CComplex = Kon*(CAg - CComplex)*CMAB - (Koff + KelAbAg)*CComplex)

    deriv(CAg = Ksyn - KelAbAg*CComplex - KelAg*(CAg - CComplex))

    Ksyn = KelAg*CAg0

    PctRO = (1-((CAg - CComplex)/CAg0))*100

    sequence{

        CComplex = 0;

        CMAB = DOSE/Vc;

        CAg = CAg0;

    }

    stparm(Vc = tvVc)

    stparm(KelmAb = tvKelmAb)

    stparm(KelAbAg = tvKelAbAg)

    stparm(Kon = tvKon)

    stparm(Koff = tvKoff)

    stparm(KelAg = tvKelAg)

    stparm(CAg0 = tvCAg0)

    fixef(tvVc = c(, 4, ))

    fixef(tvKelmAb = c(, 0.025, ))

    fixef(tvKelAbAg = c(, 0.02, ))

    fixef(tvKon = c(, 1, ))

    fixef(tvKoff = c(, 1, ))

    fixef(tvKelAg = c(, 0.7, ))

    fixef(tvCAg0 = c(, 4.5, ))

}