Dear Users,
Could you please let me know how can I get steady state parameters?
For instance, I got the PK model (see below for example).
Then I did simulation, for example: once a day for 10 days at dose of 2mg.
How do I determine when PK reached the steady state? by eyballing the PK curve?
How to determine steady state AUC, Tmax, clerance, T-half, Css, Cmin and Cmax?
Many thanks
test(){
deriv(Aa = - Ka * Aa)
deriv(A1 = Ka * Aa - Cl * C)
dosepoint(Aa)
C = A1 / V
stparm(Ka = tvKa)
stparm(V = tvV)
stparm(Cl = tvCl)
fixef(tvKa(freeze) = c(, 0.22, ))
fixef(tvV(freeze) = c(, 35487, ))
fixef(tvCl(freeze) = c(, 7643, ))
Hi YongCertara,
I assume you have a good education in pharmacokinetics.
We know that according to the theory of pharmacokinetics, you can never reach steady state!
You can only approach steady state infinitely.
You need to specify your own criteria to claim that the drug has reached a near steady state. For example, the standard is: 75% of the steady state, 87.5%, 93.75%, 96.9%, 98.4%, 99.2%, 99.8%, 99.9%, 99.99%, 99.99%.
"How to determine steady state AUC, Tmax, clerance, T-half, Css, Cmin and Cmax?"
When you get a model of the drug, you can easily calculate these parameters manually.
Of course, you can also synchronize these calculations in your PML.
I think learning the "SS" of "ML Model" will help you a lot.
https://onlinehelp.c..._More_on_Steady
Sincerely,
f_yc
