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Vd,Vz and Vss

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#1 Crystal

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Posted 05 July 2022 - 03:36 AM

Dear all,

I have difficulty calculating Vd,Vz and Vss : I can not find the equation of Vd in Certara Phoenix Assistance, does anyone know why?

And since Vss can only computed for IV Bolus and Infusion dosing, what if i want to calculate Vss for extravascular drug? can I use the equation"Vss=Dose*F/Css"?

Thanks a lot~~

 

 



#2 cradhakr

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Posted 05 July 2022 - 03:59 AM

Hi Crystal

 

This is the explanation why Vss is not calculated in oral dose.

 

 

Vss(_obs, _pred): For non-steady-state data: An estimate of the volume of distribution at steady-state based on the last observed (obs) or last predicted (pred) concentration.

= (MRTINF)(C)

Computed for IV Bolus and Infusion dosing only. Not computed for extravascular dosing (oral model 200), as MRTINF for oral models includes Mean Input Time as well as time in systemic circulation and therefore is not appropriate to use in calculating Vss.

 

aFor extravascular models (model 200), the fraction of dose absorbed cannot be estimated; therefore Volume and Clearance for these models are actually Volume/F or Clearance/F where F is the fraction of dose absorbed.

 

 

Certara Phoenix Assistance

 

Thanks and regards

Chandramouli (Mouli)


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#3 Simon Davis

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Posted 05 July 2022 - 05:47 AM

Also further up that same page; https://onlinehelp.c...5_NCA_parameter

 

I beleive the formula you are looking for is ;

 

Vz(_obs, _pred), Vz_F(_obs, _pred)a: Volume of distribution based on the terminal phase.

For non-steady-state data: = Dose/[Lambda_z(AUCINF)]


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