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SC Implant

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#1 Susan



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Posted 22 July 2022 - 09:16 PM

Is it feasible to use the IVIVC module to predict in vivo exposure from a SC implant, when the in vivo PK is flat (non-standard)?  The objective is to estimate in vivo exposure based on in vitro dissolution, but there is not a clear Cmax/Tmax/absorption phase, regardless of the implant formulation.

#2 Simon Davis

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Posted 26 July 2022 - 06:43 AM

can you perhaps post some plots of your data, how long is  absorption 'flat' for?  DO you get to see clearance kick in at all in the in vivo data?

#3 Susan



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Posted 26 July 2022 - 03:18 PM

Happy to share a graph to demonstrate.  The attachment shows a graph of in vivo exposures over 182 days, and in vitro dissolution over 150 days.




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Edited by Simon Davis, 02 August 2022 - 08:13 AM.

#4 cradhakr


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Posted 01 August 2022 - 11:40 PM

Hi Susan,


If you cant share details in the forum you could send the information to - support@certara.com




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