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high correlation between variance terms and shared approach


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#1 Davidq8

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Posted 02 September 2022 - 03:44 PM

Hi, I have a question on addressing the high correlation between variance terms with (r-value is above 0.9). Trying an alternative parametrization approach could fix this issue (shared. approach).
I am attaching a part from the published article by Mould DR, Upton RN explaining this approach, but I do not know how to do it using NLME. 
Can I get help on how to write PML for the shared approach?  
Thanks

Attached Thumbnails

  • High R.jpg

Edited by Davidq8, 02 September 2022 - 03:48 PM.


#2 cradhakr

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Posted 05 September 2022 - 02:26 AM

Hi David,

 

I have send you a ilink (youtube) which could be of use to you in converting the published data to a model

https://www.youtube....h?v=0Hr4UnT07BQ

 

 

Rebuilding a Population PK Model From a Literature Reference Presented by Bernd Wendt

 

I hope this could be of use t o you.

Rebuilding a Population PK Model From a Literature Reference Presented by Bernd Wendt



#3 kniefort

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Posted 12 September 2022 - 09:53 PM

The attached Phoenix project has 2 models, "FullBlock" with an individual eta term on each parameter, and "Shared", which shows how you can code the shared model.

 

Hope this helps!

Attached Files


Edited by kniefort, 13 September 2022 - 01:01 PM.


#4 Davidq8

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Posted 12 September 2022 - 11:05 PM

Hi David,

 

I have send you a ilink (youtube) which could be of use to you in converting the published data to a model

https://www.youtube....h?v=0Hr4UnT07BQ

 

 

Rebuilding a Population PK Model From a Literature Reference Presented by Bernd Wendt

 

I hope this could be of use t o you.

Rebuilding a Population PK Model From a Literature Reference Presented by Ber

Thanks, Cradhakr for sharing the link.



#5 Davidq8

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Posted 12 September 2022 - 11:07 PM

The attached Phoenix project has 2 models, "FullBlock" with an individual eta term on each parameter, and "Shared", which shows how you can code the shared model.

 

Hope this helps!

Thanks, Kniefort for your help, Can you please reattached the project, I think it was not attached with your post.

Best  



#6 kniefort

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Posted 13 September 2022 - 01:02 PM

Thanks, Kniefort for your help, Can you please reattached the project, I think it was not attached with your post.

Best  

 

You are correct.  Apologies.  Post above edited with attachment.



#7 Davidq8

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Posted 01 October 2022 - 02:04 AM

You are correct.  Apologies.  Post above edited with attachment.

Thank you so much for updating the post with the file!!






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