Jump to content


Photo

AUC from time last extrapolated to infinity


  • Please log in to reply
2 replies to this topic

#1 seitzbri

seitzbri

    Newbie

  • Members
  • Pip
  • 2 posts

Posted 13 September 2022 - 01:38 PM

Hello,

 

How does one calculate within NCA the PK parameter AUCt-INF (AUC from time last extrapolated to infinity)?

 

Thanks for your help!



#2 Simon Davis

Simon Davis

    Advanced Member

  • Administrators
  • 1,255 posts

Posted 13 September 2022 - 02:08 PM

I would use the simple calculation of AUCinf-AUCtz

You can do this in a data wizard or in  Phoenix 8.1 onwards using the the "user defined parameters" in the NCA object itself, see below;

 

 Simon.

Attached Thumbnails

  • auctz_inf.jpg

Attached Files


  • seitzbri likes this

#3 seitzbri

seitzbri

    Newbie

  • Members
  • Pip
  • 2 posts

Posted 26 September 2022 - 12:46 PM

I would use the simple calculation of AUCinf-AUCtz

You can do this in a data wizard or in  Phoenix 8.1 onwards using the the "user defined parameters" in the NCA object itself, see below;

 

 Simon

Thank you!






0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users