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AUC from time last extrapolated to infinity


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#1 seitzbri

seitzbri

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Posted 13 September 2022 - 01:38 PM

Hello,

 

How does one calculate within NCA the PK parameter AUCt-INF (AUC from time last extrapolated to infinity)?

 

Thanks for your help!



#2 Simon Davis

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Posted 13 September 2022 - 02:08 PM

I would use the simple calculation of AUCinf-AUCtz

You can do this in a data wizard or in  Phoenix 8.1 onwards using the the "user defined parameters" in the NCA object itself, see below;

 

 Simon.

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#3 seitzbri

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Posted 26 September 2022 - 12:46 PM

I would use the simple calculation of AUCinf-AUCtz

You can do this in a data wizard or in  Phoenix 8.1 onwards using the the "user defined parameters" in the NCA object itself, see below;

 

 Simon

Thank you!






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