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Least Square PK model


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#1 sjpan

sjpan

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Posted 23 September 2022 - 12:03 PM

Hello,

 

In PK Model 2: IV-infusion input, 1-compartment, no lag, 1st elimination (under the Least-squares regression models), V (volume) is one of the estimated parameters whereas Vss is a clearance secondary parameters. What is the V here? the Vz, Vc or ? How is Vss calculated in this case?

 

Thank you very much for your help.

 

SJ

 



#2 bwendt@certara.com

bwendt@certara.com

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Posted 23 September 2022 - 12:20 PM

Hi,

 

there is detailed information in our online help:

 

https://onlinehelp.c...tocid=_33_3_4_1

 

You can find information about the formula for secondary parameters by:

 

1. insert a Phoenix Model object into your workflow

2. Setting a WNL model:

wnl.png

3. pick Model 2 and click Apply

list.png

 

4. look at Parameters>>Secondary Tab in the bottom panel:

secondary.png

 

Let me know if this does not help.

 

Bernd






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