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Modeling Extended/slow Release Formulation

Extended Release Slow Release Formulation Multiple Absorption transit transit compartment Two Peaks

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#1 Wafaanasser94

Wafaanasser94

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Posted 07 November 2022 - 09:52 PM

Hello,

 

I am trying to build a pop-pk model for an extended/slow release formulation that was administered at 5 mg/kg  Intraperitoneal injection ( IP )

 

I tried several models like Enterohepatic Recirculation , Transit model , change in absorption rate model and Multiple Absorption Routes (like modeling buccal  Nitroglycerin  ) .

 

Yet none of these models described the observed data correctly

 

Can someone look at the attached file and see what I am doing wrong .

https://drive.google...Z-8?usp=sharing

 

 

Thank you ,

Wafaa

 
 



#2 bwendt@certara.com

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Posted 08 November 2022 - 08:59 AM

I have troubles opening the link. Would you be able to upload the file directly to the forum. Alternatively, you could send to support@certara.com as attachment.

 

Thanks,

Bernd



#3 Wafaanasser94

Wafaanasser94

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Posted 08 November 2022 - 01:26 PM

I have troubles opening the link. Would you be able to upload the file directly to the forum. Alternatively, you could send to support@certara.com as attachment.

 

Thanks,

Bernd

I wasn't able to upload it directly to the forum , I will send it to the support@certara.com in an email with the same title. Thank you







Also tagged with one or more of these keywords: Extended Release, Slow Release, Formulation, Multiple Absorption, transit, transit compartment, Two Peaks

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