Hello,
I am trying to build a pop-pk model for an extended/slow release formulation that was administered at 5 mg/kg Intraperitoneal injection ( IP )
I tried several models like Enterohepatic Recirculation , Transit model , change in absorption rate model and Multiple Absorption Routes (like modeling buccal Nitroglycerin ) .
Yet none of these models described the observed data correctly
Can someone look at the attached file and see what I am doing wrong .
https://drive.google...Z-8?usp=sharing
Thank you ,
Wafaa