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Two absorption compartment and ADDL


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#1 vetpharma

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Posted 28 February 2023 - 04:32 PM

Hi, 

 

I am modeling a compound that has mix of IR and SR formulations. The data are from a clinical trial with three times administration a day and sampling at day 18. I defined two absorption compartment with Tlag on the second one. The problem is when I use ADDL the Ka2 appears after Ka1 (cycle time 48 h). however, when I use actual time of administration (as single dose) Ka1 and Ka2 are at their correct time. I would appreciate it if you help me with this issue. How can I use delta time to count for cycle time of 24 hours without giving Ka2 after Ka1. I would like to have them at the right time of administration. 

(model is attached)

 

Kind regards

Amir



#2 cradhakr

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Posted 28 February 2023 - 10:02 PM

Hi Amir,

 

Thanks for reaching out. We did not receive the project file - could you please attach it again or you could e-mail to support@certara.com.

 

Thanks

Mouli



#3 vetpharma

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Posted 28 February 2023 - 10:42 PM

Hi Amir,

 

Thanks for reaching out. We did not receive the project file - could you please attach it again or you could e-mail to support@certara.com.

 

Thanks

Mouli

Hi Mouli,

 

Sorry I forgot to press attach at the end. Now, I think you get it.

 

Best

Amir

Attached Files



#4 cradhakr

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Posted 01 March 2023 - 10:49 AM

Hi Amir,

 

I have attached the project file for you. I have split the data and did the analysis for one subject. For each formulation I created a row (see NBI_OPC_1722_10011001 from Split).

 

Please have a look and let me know if this is what you  are looking for.

 

If you need some further clarification please reachout to us on support@certara.com and I shall organise for a quick teams session.

 

Thanks

Mouli

Attached Files


Edited by cradhakr, 01 March 2023 - 10:50 AM.


#5 smouksassi1

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Posted 01 March 2023 - 12:00 PM

adding link to the ADDL documentation

https://onlinehelp.c...m=ADDL&rhsyns=

 

please have a special look at Specifying steady state and additional doses outside of the user interface
 sscol(SS)
 iicol(II)
 ssoffcol(SSOffset)






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