Jump to content


Photo

A three-compartment elimination model of endogenous toxins

dialysis

  • Please log in to reply
4 replies to this topic

#1 GuXJ

GuXJ

    Newbie

  • Members
  • Pip
  • 3 posts

Posted 09 March 2023 - 04:00 AM

Dear Certara team,
  We constructed a three-compartment model for intravenous infusion of endogenous toxins during hemodialysis. When the Phoenix model was used to simulate our pharmacokinetic parameters, the model could not be accurately fitted due to the presence of initial toxin concentrations in the blood. I hope to get your help.

Attached Files


Edited by GuXJ, 09 March 2023 - 07:37 AM.


#2 cradhakr

cradhakr

    Advanced Member

  • Administrators
  • 78 posts

Posted 09 March 2023 - 06:31 AM

Hu Gu,

 

Thanks for sharing the project file. I was able to fix the model with 2 compartment. Please have a look and let me know if you would like to go through this.

 

Thanks and regards

Mouli

Attached Files


Edited by cradhakr, 09 March 2023 - 11:10 AM.


#3 GuXJ

GuXJ

    Newbie

  • Members
  • Pip
  • 3 posts

Posted 09 March 2023 - 08:04 AM

Dear Mouli,

   Thanks for your projrct file.To simulate the physiology, we need to use an intravenous infusion model. But endogenous toxins were present in the blood before intravenous infusion, that's the concentration point in our data at time zero.And we wanted to know how to fit them in the intravenous infusion model.

   Thanks and regards

   Gu


Edited by GuXJ, 09 March 2023 - 08:04 AM.


#4 cradhakr

cradhakr

    Advanced Member

  • Administrators
  • 78 posts

Posted 09 March 2023 - 11:09 AM

Dear Gu,

 

Apologies I uploaded a wrong project file. Please see the correct one. You need to use a sequence statement to sort this issue.

Attached Files



#5 GuXJ

GuXJ

    Newbie

  • Members
  • Pip
  • 3 posts

Posted 10 March 2023 - 01:31 AM

cradhakr, 在 09 三月 2023 - 7:09 下午, 说:

亲爱的顾,

 

抱歉,我上传了错误的项目文件。请看正确的。您需要使用序列语句对此问题进行排序。

Thanks a lot,it's just what I need.







Also tagged with one or more of these keywords: dialysis

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users