4 replies to this topic

[GuXJ]

Dear Certara team,

  We constructed a three-compartment model for intravenous infusion of endogenous toxins during hemodialysis. When the Phoenix model was used to simulate our pharmacokinetic parameters, the model could not be accurately fitted due to the presence of initial toxin concentrations in the blood. I hope to get your help.

Attached Files

•  IS dialysis.phxproj   339.17KB   96 downloads

Edited by GuXJ, 09 March 2023 - 07:37 AM.

[cradhakr]

Hu Gu,

 

Thanks for sharing the project file. I was able to fix the model with 2 compartment. Please have a look and let me know if you would like to go through this.

 

Thanks and regards

Mouli

Attached Files

•  ISdialysis.phxproj   385.25KB   105 downloads

Edited by cradhakr, 09 March 2023 - 11:10 AM.

[GuXJ]

Dear Mouli,

   Thanks for your projrct file.To simulate the physiology, we need to use an intravenous infusion model. But endogenous toxins were present in the blood before intravenous infusion, that's the concentration point in our data at time zero.And we wanted to know how to fit them in the intravenous infusion model.

   Thanks and regards

   Gu

Edited by GuXJ, 09 March 2023 - 08:04 AM.

[cradhakr]

Dear Gu,

 

Apologies I uploaded a wrong project file. Please see the correct one. You need to use a sequence statement to sort this issue.

Attached Files

•  ISdialysis.phxproj   393.76KB   108 downloads

[GuXJ]

cradhakr， 在 09 三月 2023 - 7：09 下午， 说：

亲爱的顾，

 

抱歉，我上传了错误的项目文件。请看正确的。您需要使用序列语句对此问题进行排序。

Thanks a lot,it's just what I need.