Hi All, relatively new user of Phoenix here with a question/ problem.
I have concentration time data that I want to do NCA on.
Lets say for example, I want to calculate AUC (h*nmol/L) and AUC/dose, but for dose, I don't want to use nmol/kg, I want to use mg/kg. So the units should be h*kg*nmol/L/mg.
When I can calculate based on molar dose (h*kg*nmol/L/nmol) my NCA will be fine, but this is not the output I want.
The problem is that when I do a dose normalization for mg/kg to get h*kg*nmol/L/mg, (which is easy using the dose options interface) other parameters are miscalculated and with the wrong units.
For example I want to calculate clearance with the units mL/min/kg. However when I do the dose normalization for mg to get the desired AUC/dose calculation and units, the units are forced to {mg/(h*nmol/L)kg}, giving an undesired calculation and output.
So I can either set up my NCA so that I get the correct AUC/dose, or the correct clearance, but not both.
Perhaps I am doing something wrong, not sure. Any advice?