5 replies to this topic

[rezkighassani]

Greetings,

 

I would like to ask what is the difference between Fraction Drug Dissolved and Fraction Drug Absorbed? Then how to calculate these 2 parameters.

 

Thank you.

[Simon Davis]

FDiss is from an in vitro experiment where you measure the form dissolving.

FAbs is assessed in vivo as to what fraction of drug is absorbed, you may think of it as Bioavailabilty being calculated over time.

[rezkighassani]

So I just need to see how many mg are dissolved in a given time in order to calculate FDiss?

[Simon Davis]

normally you use defined apparatus and media to replicate GI tract as defined in   United States Pharmacopeia (USP)  e.g.  Apparatus 1 (baskets), 2 (paddles), 3 (reciprocating cylinder), 5 (paddle over disk), 6 (rotating cylinder), and 7 (reciprocating disk).

[rezkighassani]

Okay thank you for your explanation.

[Simon Davis]

Exciting times  - I am now locking this whole forum as we have migrated to the new;

 

https://forum.certara.com/c/phoenix

All posts and user accounts have been migrated.

 

To be able to post, follow threads etc, you will need to login in via CAD*

This is the my.certara.net identity that you are using for Phoenix 8.5 licensing etc.

 

Note this is normally your organisations address, but you can change the display 'alias' once you login so that your full identity is masked from other users when you post if you desire.

 

If you've used a gmail or similar on here, please contact me or support@certara.com and I think I should be able to tie you CAD ID to your old posting history if you want too.

 

 Hope you all enjoy the new forum, we'll be making a few tweaks to the look and feel so let me know if you have any comments, otherwise you should be able to get started straight away -  looking forward to some good discussions,

  Simon.

* see ...and

https://help.certara...g-certara-admin