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How to generate the initial estimate

Started by David , Oct 21 2024 08:12 PM
study design Pk Model ML model

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#1 David

David

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Posted 21 October 2024 - 08:12 PM

The phoenix WinNonlin 8.3 provided VIF based study-design example (study-design project attached).

 

 

I am wondering how the initial estimates V_F=10, K01=3, K10=0.05 generated because non one of initial estimates from PK or ML model generated such results (Pk model project attached)

 

Please see details in the attached study-design question.

 

Thanks 

 

DV

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