1 reply to this topic

[David]

Hi all,

 

I am conducting a model-based simulation using PK parameters from a publication. The publication reports: "Effect of Study A on residual unexplained variability (RUV) is -0.455; 12.8 (parameters: RES)." How should I incorporate RUV into the population PK model?

 

I attempted to define RUV as a parameter (graph model) and included Study A as a covariate , but it does not seem to work well.(reduced model attached)

 

I would greatly appreciate any guidance on how to properly implement this.

 

DV

 

 

Attached Files

•  RUV_ABF.phxproj   275.44KB   2 downloads

[Simon Davis]

sorry David would you mind going to  https://forum.certara.com/c/phoenix/and re-posting your question there?

 

Since I am about to lock this old forum, thanks.
 

You should be able to sign in with the account you have in Certara Admin (CAD) for your phoenix license.

 

You may use the ‘bell’ icon to set your notifications by category or thread.

 

 

I can also merge your old accounts into one so all your post history is maintained under one profile.