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TIP: How to add biovailability in my PML model

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#1 Ana Henry

Ana Henry

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Posted 14 September 2011 - 02:57 PM

In order to estimate biovailabilty in a PML model you can add the following code to the dosepoint of the absorption compartment


dosepoint(Aa, bioavail = F)


and then deifne the parameter F and its initial values


stparm(F = ....)

fixef (F= c(0,0.5,1))

#2 Jason Chittenden

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Posted 14 September 2011 - 03:24 PM

I'll add to this topic. If you want to have a random effect on bioavailability, you'll want to limit the support of the structural parameter to values between (but not including) zero and one, like this:


stparm( F = ilogit( tvpF + npF) )

fixef( tvpF = 0) #some initial value

ranef(...,npF,...) = ...


ilogit is the inverse logit function, or logistic function. I use the "p" in my variables to remind myself that these values undergo a logistic transformation.

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