4 replies to this topic

[Minaxi]

Hi

 

Can you please explain what exactly is meant by V_F, K01 and K10. How and from where to get these values?

 

Thanks and regards,

 

Minaxi Vora

[Helmut Schütz]

Hi Minaxi!

Can you please explain what exactly is meant by V_F, K01 and K10.

See the User’s Guide page 625.
V is the volume of distribution. F is the (absolute) bioavailability (range 0-1). The latter is unknown if fitting extravascular data.
K01 is the absorption rate constant (unit 1/time) and (transfer to "outside" = "0" to the central compartment "1"). K10 is the elimination rate constant (from !1" to "outside").

How and from where to get these values?

From a model fit of your data or from the literature.

[Minaxi]

Hi

I am not very clear. Is it possible to perform Steady State Simulation using Model No. 3 for the attached data and explain?

I have tried to do the same but not very sure whether I have done it correctly. I have also attached the charts obtd. on performing SS using Model 3, considering 12mg dose given for 12 days.

/extranet/media/kunena/attachments/legacy/images/SS_pk.JPG

thanks and regards,

Minaxi Vora

[Simon Davis]

Hi Minaxi - as you probably noticed there are a couple of issues with attachments in the forum - I edited your message to display your graph.

 

  Looking at your graph it seems you have simulated 12 doses OK, but without knowing what your original single-dose data was like or from what dose it was obtained I can't say if this is correct. I think you should be clearer in what question you are trying to answer, PK theory suggests steady-state is obtained in 5-7 half-lives, so performing a simulation isn't 'proving' whether SS has been obtained - is there a minimal conc you want ot maintain, or a maximum conc you want to stay below? Are you interested in secondary parameters like Cmax, AUC etc. or in defining what sampling schedule would be good for a proposed sampling design?

 

  Simon.

[Minaxi]

Hi Simon,

 

I think the file with initial data to be simulated was not attached properly. I had attached file with time-conc data and the graphs.

 

I am resending the file for your reference. If you can just run it for steady state simulation and explain, I would be highly obliged.

 

Thanks and regards,

 

Minaxi Vora

 

NB: I think .pwo file is not being attached, I have reattached .xls file

Sorry for inconvenience [file name=SS_data_020412.xls size=23040]http://pharsight.com/extranet/media/kunena/attachments/legacy/files/SS_data_020412.xls[/file]