Using Phoenix Nonlin (NCA module) the opportunity is presented for normalizing the PK paramaters such as AUC for dose administered, so that a total exposure value is given per unit mass drug administered ( e.g. mg). Now supposing one wanted to further normalize this vaue for body weight of the subject? There would of course be a column including the body weight of each of the individual subjects in the study together wiht the usual columns like time plasma concentrations e.tc.. Is this easy to do in Phoenix? It will involve dividing one column ( total exposure value is given per unit mass drug administered) by another column (body weight), but how to do that in Phoenix? Or is it better done by exporting to Excel and doing that normalization there.
Angus