Hi,
I am doing a PBPK simulation to see portal and plasma conc. I am facing problem in poting Dose point/GI equation. Equation are written below;
Kindly let me know about GI equation and initial condition for GI
Init GI=0
Init Portal=0
Init Liver=0
Init Plasma=0
d/dt(GI)= -Dnmole*ka*FaFg
d/dt(Portal) = (Qp*Plasma+Dnmole*ka*FaFg*exp(-ka*time)-Qp*Portal)/Vp
d/dt(Liver) = ( Qa*Plasma + Qp*Portal-Qh*(Liver/Kp)-CLh*(Liver/Kp))/Vl
d/dt(Plasma) = (Qh*(Liver/Kp)-Qh*Plasma-CLnh*Plasma)/Vc
Qh=(55*60)/1000
Qp=(32.9*60)/1000
Qa=Qh-Qp
CLnh=(5*60)/1000
CLh=(45*60)/1000
Vc=31/1000
Vl=78/1000
Vp=8/1000
ka=1.5
FaFg=0.9
Kp=1
Dose=5
Dnmole=Dose*1000000/MWt
MWt=500 [file name=gi_portal_liver_plasma.xls size=11264]http://pharsight.com/extranet/media/kunena/attachments/legacy/files/gi_portal_liver_plasma.xls[/file]