I have performed a NCA data analysis from a parallel goup design ( 5 treatment groups). I hae made a Table from the raw data and it has almost the format I want. I have column stratified the data stratified the data by Treatment and Time. I was expecting the Time to be organized as increasing ( i.e. 0, 2,3,4............). Now it does not do this completely (see snapshot). I intended to do column statistics for each of the timepoints of each treatment group. Any suggestion to get the series of times presented in order of the time.
column STRATIFICATION NCA TABLE
Posted 08 September 2013 - 11:31 PM
Posted 09 September 2013 - 09:07 AM
On the plus side it's very easy to resolve. In your table object choose the tab in the lower panel Column/Sort order
Highlight the Column Stratification field TIME
Click on the button "Add Column Sort" and you can now specify whatever order you want; in my case just choosing this button and re-executing actually brought the sort back to correct alphanumeric order
(I am using 6.3.1, i.e. 6.3 with the Reporter patch applied.)
Note other stratification variables can be custom sorted in this manner too, particularly useful for things like Gender.
Posted 09 September 2013 - 01:27 PM
Simon: Thanks for the advice. I am trying to learn to use the database focusing on stratification opportunities. Clearly I must move away from Excel as much as I can. Your suggestion works. It is add that it did not sort the numbers is the usual order without my specifying it. When I added custom sort then it did include the column times in ascendng order.
I do have Gender in database so I will look out to use this tip. Quite often I find myself not understanding well what I accomplish when making the Tables and using row -column strafification.
It seems that ccolumn stratificaion is the way one shoud work. Often in the literature ofr exaple entration time profiles are presented row stratified.withthe descrptive statistics to the right.
Posted 09 September 2013 - 02:19 PM
Here are the details for installing this additional plugin (licensed with Connect so if you don't have that license then you won't see anything different)
Note that this is a patch installer which will patch an existing PHX 1.3 (build is 188.8.131.525) installation, it will be rolled into the 1.4 release.
This info was already posted here; http://www.pharsight...=46&id=932#1574 but I appreciate without a notification of new topics it's hard to be aware.
In short I personally would install the patch and try it out with a test license of Connect if I didn't have one already to see if the new functionality would help.
However I don't expect it to make any difference to Tables in themselves and you and i appear to both see the same behaviour so I'm following up with Product Management.
Posted 10 September 2013 - 07:32 PM
regarding your last question;
It seems that column stratification is the way one should work. Often in the literature for example concentration time profiles are presented row stratified.with the descriptive statistics to the right.
that's easy-ish too, using the choice of RowStatisitcs;
Row ID : Time_post_dose [h]
Data : Sample_Concentration [ng/mL]
Row : PK_Day
Column : Subject
Posted 10 September 2013 - 08:22 PM
Simon: Thank you for your comments: Yes; row stratification does work, but you must have at least one variable column stratified. For me I used the subject number was column stratified. Row ID was :"time" and plasma conc. as "data". Then got the concentations at the timeppoints organized by column downwards and across row and did the row statistics across the rows. You have to get used to the terminology.
Posted 14 November 2013 - 03:10 PM
Webinar: Standardising TK and other NCA analysis reports with Phoenix Connect
Date and Time:
November 15, 2013
10am London (11am Paris, 3:30pm Mumbai)
Would you like to cut hours off the time you spend making study reports from PK/PD analyses conducted in Phoenix? In this webinar, we will show you how to streamline report generation with Phoenix Connect's Reporter. This tool allows users to construct a report within the Phoenix workflow and have the graphs, tables and listings generated by WinNonlin as well as third-party tools like SAS, NONMEM and R inserted directly into their Word report template. This demonstration will focus on a bioavailability protocol but examples of other uses will be discussed and questions will be encouraged during the WebEx.
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