Hi,
can I get someone to verify my project is set up correctly to obtain an estimate for "F" from IV and SC data?
I am following the examples guide but the example doesn't have the F in the model.
I'm assuming if bioavailabilty for IV =1, then bioavailabilty for SC = F*1 in the model.
But my initial estimates are quite different from my NCA results.
for example my NCA suggests F = 0.88
V (from IV) = 48 L/kg
CL (from IV) = L/hr/kg
this is a small peptide so I'm not surprised NCA doesn't match up so closely but I'm surprisde by the orders of magnitude they are off by.
Can someone double check my logic that my model is set up correctly for an absolute bioavailability model?
thanks
Elliot [file name=Cyno_IVSC.phxproj size=351242]http://www.pharsight.com/extranet/media/kunena/attachments/legacy/files/Cyno_IVSC.phxproj[/file]