Hello,
I have developed a joint parent-metabolite model for cyclophosphamide. I've run separate POPPK models for the parent and the metabolite (4-OH Cy) which were robust. I found a correlation between Kel (parent drug) and Kform (metabolite, but I use Ka symbol in my code), so I added a linear correlation. My issue is that I keep getting a point in my graph (-5.33, -5.33), which I can't find in my data and I don't know whether I set up my data sheet correctly, since I 've added BQL and MDV model #2. I also don't know if because of this point I get high sd.
Could you please help me by taking a look in my project? I would really appreciate your feedback.
Thanks,
Georgia
P.S. I am trying to upload my project here and I can't.