Posted 16 June 2014 - 12:19 PM
I should have attached the updated project file..as I did fix those syntax errors.
Here is a copy of the code. In a previous set of postings Serge Guzy suggested that one could simulate a distribution of body weights in the model code, thus simplifying the input template worksheet.
So I was attempting to integrate this into the simulation.
Another question I have is if the dose is to be a ug/kg then should all the fixed effect typical values be normalized (where applicable) by body weight as well, or is there a means of coding this in the text?
I can get it to work as a built-in model when I use R to generate my weight distribution and include it in the simulation template worksheet but would like to be able to do this in 1 step instead of 2 and Serge suggested it was possible.
So the dose is 3 mg/kg (3000 ug/kg since my CObs is ug) and duration of infusion is 1.5 hours as a fixed infusion time.
deriv(A1 = - (Cl * C)- (A1 * K12- A2 * K21))
urinecpt(A0 = (Cl * C))
deriv(A2 = (A1 * K12- A2 * K21))
C = A1 / V
dosepoint(A1, duration = (1.5), idosevar = A1Dose, infdosevar = A1InfDose, infratevar = A1InfRate)
error(CEps = 1)
observe(CObs = C + CEps * (1 + C * CMixRatio))
stparm(V = tvV * (Weight/median(Weight))^dVdWeight * (1+dVdGender0*(Gender==0)) * exp(nV))
stparm(Cl = tvCl * (Weight/median(Weight))^dCldWeight * (1+dCldGender0*(Gender==0)) * exp(nCl))
stparm(K12 = tvK12)
stparm(K21 = tvK21)
stparm(CMixRatio = tvCMixRatio)
stparm(Weight=tvWeight*exp(nWeight)) #here I am attempting to define Weight as a distribution with a mean of 70 kg and CV of 30%.
fixef(tvV = c(, 2660, ))
fixef(tvCl = c(, 8.625, ))
fixef(tvK12 = c(, 0.00929, ))
fixef(tvK21 = c(, 0.00896, ))
fixef(tvCMixRatio = c(, 0.0236, ))
fixef(dVdGender0(enable=1) = c(, 0.221, )) # can I delete this "enable=..."?
fixef(dCldGender0(enable=2) = c(, 0.207, ))
fixef(dVdWeight(enable=4) = c(, 0.411, ))
fixef(dCldWeight(enable=8) = c(, 0.368, ))
ranef(diag(nV, nCl) = c(0.0676, 0.0282))