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Levy plot

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#1 Chandramouli1412845459

Chandramouli1412845459

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Posted 12 August 2014 - 03:51 AM

Hi

I am getting only 40% of the drug absorbed? is this right? Also, let me know if you need more information from my side.



#2 Simon Davis

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Posted 12 August 2014 - 08:23 AM

Quite possibly - it depends on the compound you are dosing some drugs have even lower effective bioavailability, e.g.

 

pyridostigmine (around 7.5% I believe because it is poorly absorbed and largely excreted unchanged

 and domperidone (~17%). as it has a high first pass effect.

 

Hope that helps.

 

  Simon.



#3 Chandramouli1412845459

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Posted 12 August 2014 - 12:02 PM

Hi Simone,

 

Thanks for your response.. The drug i am using is Paracetamol and we are using Saliva to measure the levels. Also, i am using simulated IV infusion as a reference formulation. If i am using oral as a "Reference Data type" my output is different. If i am right the bio availability is influencing the levy plot and thats the difference i am seeing in the plot am i right.

 

kid regards

Mouli



#4 Simon Davis

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Posted 12 August 2014 - 12:06 PM

Yes it sounds like it, would be much easier to confirm if you post your project as an attachment to double check your settings. I believe paracetamol's oral bioavailability (~70-90%) is somewhat dose dependant: with larger doses, the hepatic first pass effect is reduced due to overwhelming of the liver enzymatic capacity.

 

  Simon






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