Dear Forum Members,
We have just purchased WinNonLin with and IVIVC Toolkit license. I am novice to the software. To establish correlation, i have in-vitro dissolution and corresponding in-vivo data of 3 formulations (tablets) and i want to predict the in-vivo behavior of the 4th formulation (also a tablet), for which i have the in-vitro data.
I would like to know if the available oral data is sufficient for using the IVIVC toolkit and to approximate the in-vivo behavior of 4th formulation.
I tried following the demo examples provided. However, it is confusing, in that the examples have the data on the IV route but we do not select the data while computing the values. Running the IVIVC software, gave error messages, even when i took utmost care to arrange the data in the similiar way as in the examples, but without IV data. So is the IV data mandatory to establish IVIVC. Please guide.