I tried to simulate PK and PD of one of our candidate molecule using phoenix model.
With the projected PK parameters from in vitro studies PK profile was simulated and saved the model. The same model was copied as PK/Emax and PK was frozen. PD parameters were given in parameters tab.
The receptor occupancy was simulated over time but the Yvar name didnt change to E (Effect) automatically and it is named as DV. However changed the Y axis title to RO % by in the label tab.
Am i missing anything and please guide me the simulation process is ok,
Attached project file for your review,
With best regards,