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*** ERROR 10164 *** THE NOBS VALUES ARE INCONSISTENT WITH THE NUMBER OF RECORDS ON THE DATA FILE


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#1 santosh kumar

santosh kumar

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Posted 20 February 2015 - 07:11 AM

When I was trying to predict PK profile for test data I got following error  *** ERROR 10164 ***  THE NOBS VALUES ARE INCONSISTENT
  WITH THE NUMBER OF RECORDS ON THE DATA FILE
. Kindly help me

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#2 Simon Davis

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Posted 23 February 2015 - 12:36 PM

Santosh, the problem seems to be that you have quantifiable values at time zero for F-101, F-105 and Target in you in vivo data which for an oral profile is unexpected;

 

this means it only has F-108 availabe later, and then you get the message about mis-matched numbers of formulations.  If you 'spoof' the file to give a time later than dose time e.g. 0.01 then you will predict PK but it' doesn't look great;

 

Formulation    Parameter    Predicted    Target    %PE    Ratio
MKT    AUClast    55173.976    38891.494    41.866437    1.4186644
MKT    Cmax    4304.0733    4950    -13.049024    0.86950976

 

Actually looking back at the Correlation validation that indicates you need to work on your model and or formulations before you can expect a resonable prediction success.

 

Formulation    Parameter    Predicted    Observed    %PE    Ratio
F-105 Internal    AUClast    55173.976    38891.494    41.866437    1.4186644
F-105 Internal    Cmax    4304.0733    4950    -13.049024    0.86950976
F-108 Internal    AUClast    67868.318    78911.141    -13.993997    0.86006003
F-108 Internal    Cmax    5010.6924    7040    -28.825392    0.71174608
Avg Internal    AUClast    61521.147    58901.318    27.930217    1.0444783
Avg Internal    Cmax    4657.3829    5995    20.937208    0.77687788


 

   Simon

Attached Thumbnails

  • NON_zero.jpg
  • zero_times.jpg

Edited by Simon Davis, 23 February 2015 - 12:47 PM.
adding comment about Validation


#3 santosh kumar

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Posted 23 February 2015 - 02:33 PM

Thank you very much Simon






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