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ivivc predction problem

ivivc predction problem

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#1 sachintulsankar7777@gmail.com

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Posted 25 February 2015 - 09:37 AM

 Hi, our lab recently purchased phoenix ivivc toolkit. We want to predict data for marketed preparation but we are getting following status

 

"Failed Execution
There are no In-Vivo formulations that match the In-Vitro Target Batch.  Please use a different dataset"

 

 

I am attaching my project file. Please guide us

Attached File  IVIVC S_644.phxproj   4.84MB   245 downloads



#2 Wendt

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Posted 26 February 2015 - 09:34 AM

Hi Sachin,

 

 

there were two problems with your data:

 

1. the in vitro profiles consist of only 5 data points each, this causes difficulties to fit. You can get fits for one (F-108) or the other (F-105) but not for all formulations. In order to generate a model with all formulations I have used the raw data.

 

2. The formulation name of the target formulation is different in the in vitro and the in vivo data. After fixing the name the model can be generated and used for predictions. 

 

Please see project file attached. <project file exceeded 12Mb limit, sent to Sachin directly>

 

Cheers,

Bernd

Attached Thumbnails

  • Targ_TARG.jpg

Edited by Simon Davis, 27 February 2015 - 06:42 AM.
added image to show replacing TARG with Targ

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#3 sachintulsankar7777@gmail.com

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Posted 26 February 2015 - 12:01 PM

Thank you very much sir, your suggestions helped me a lot



#4 minikingrus

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Posted 10 May 2018 - 03:08 AM

Thank you very much sir, your suggestions helped me a lot






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