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Non-linear correlation using IVIVC Toolkit

IVIVC non-linear correlation User Specified correlation

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#1 Senka Radosevic

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Posted 02 March 2015 - 01:18 PM

Hi,

I am working on IVIVC case for modified release product, and I am able to get only linear correlation FraAbs vs FraDiss (using IVIVC Toolkit).

However, it’s likely that there is a correlation, but not linear.

 

Questions:

Is there a possibility to get non-linear equation using IVIVC Toolkit?

How to do that?

Is it possible to set one correlation equation up to e.g. 20% dissolved, and another correlation equation for later ?

 

Thanks in advance

Senka



#2 Simon Davis

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Posted 02 March 2015 - 06:17 PM

Sure Senka it's possible;  Select the User Specified option button to create a custom correlation model using the WinNonlin ASCII modeling language.  There is some info in the Phoenix IVIVC Toolkit 2.2 User's Guide.pdf as well an example of custom code on here;

 

http://www.certara.c...osters/?hl=aaps

 

Please let us know how you get on.

  Simon.



#3 Simon Davis

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Posted 22 March 2017 - 02:26 PM

Someone recently asked for more details on the ASCII code to help with writing their IVIVC user models, for those of you that this would help; please look at Chapter 10, User Models in the attached WinNonlin 5.3 User guide.

 

  Simon.

Attached Files



#4 harishkaushik

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Posted 13 November 2019 - 06:26 AM

Hello Simon,

Can you share an example code for doing the same or example project

 

Regards

Harish



#5 Simon Davis

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Posted 14 November 2019 - 09:36 AM

Harish, please follow the link in post number 2!

 

  Simon.



#6 harishkaushik

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Posted 10 December 2021 - 11:16 AM

Hello Simon,

 

I have read an article on "developing Nonlienar IVIVC for Upadacitinib" where the authors have used A user-specified non-linear IVIVC was evaluated by fitting a non-linear Emax model to scale the Tvitro to the Tvivo 

How can we code the same in IVIVC, any insights will help

 

Link to the paper

https://link.springe...2248-019-0378-y

 

Regards

Harish



#7 Nuno Elvas Silva

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Posted 07 March 2022 - 05:10 PM

Dear all

 

I'm also trying to build a non-linear correlation using Upadacitinib paper as example. In the paper a non-linear Emax model to scale the Tvitro to the Tvivo was implemented:

 

Tvitro = ((A1*Tvivo)/(A2+Tvivo))-B2

 

I'm using the following code:

 

T = ((A1 * X)/(A2 * X))
IF T > 0 THEN
  DISS = IVINTERP(T)
ELSE
  DISS = 0
ENDIF
F = A1 * DISS
 
When checking, a message shows up:
 
*** ERROR 10031 *** ATTEMPT TO DIVIDE BY ZERO.  PROGRAM TERMINATED.   Line =   3:   Variable = -------------------------------------------------------------------OK

 

And it is not possible to Build Correlation.

 

Any suggestion how to implement such a non linear time scaling?



#8 Simon Davis

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Posted 08 March 2022 - 12:08 AM

Nuno can you email your project to support@certara.com for us to take a look.







Also tagged with one or more of these keywords: IVIVC, non-linear correlation, User Specified correlation

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