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Non-linear correlation using IVIVC Toolkit

IVIVC non-linear correlation User Specified correlation

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#1 Senka Radosevic

Senka Radosevic

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Posted 02 March 2015 - 01:18 PM

Hi,

I am working on IVIVC case for modified release product, and I am able to get only linear correlation FraAbs vs FraDiss (using IVIVC Toolkit).

However, it’s likely that there is a correlation, but not linear.

 

Questions:

Is there a possibility to get non-linear equation using IVIVC Toolkit?

How to do that?

Is it possible to set one correlation equation up to e.g. 20% dissolved, and another correlation equation for later ?

 

Thanks in advance

Senka



#2 Simon Davis

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Posted 02 March 2015 - 06:17 PM

Sure Senka it's possible;  Select the User Specified option button to create a custom correlation model using the WinNonlin ASCII modeling language.  There is some info in the Phoenix IVIVC Toolkit 2.2 User's Guide.pdf as well an example of custom code on here;

 

http://www.certara.c...osters/?hl=aaps

 

Please let us know how you get on.

  Simon.



#3 Simon Davis

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Posted 22 March 2017 - 02:26 PM

Someone recently asked for more details on the ASCII code to help with writing their IVIVC user models, for those of you that this would help; please look at Chapter 10, User Models in the attached WinNonlin 5.3 User guide.

 

  Simon.

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#4 harishkaushik

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Posted 13 November 2019 - 06:26 AM

Hello Simon,

Can you share an example code for doing the same or example project

 

Regards

Harish



#5 Simon Davis

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Posted 14 November 2019 - 09:36 AM

Harish, please follow the link in post number 2!

 

  Simon.







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