4 replies to this topic

[Igor Vostiar]

Is it possible to fit simultaneously SC and IV data, using different models depending on the route of administration but sharing a subset of model parameters? (A similar problem is described here: http://learnpkpd.com...imultaneously/)

 

[serge guzy]

Is it possible to fit simultaneously SC and IV data, using different models depending on the route of administration but sharing a subset of model parameters? (A similar problem is described here: http://learnpkpd.com...imultaneously/)

Dear Igor

The answer is Yes and I made an example for you. I hope I understood the question right.

In the attached project (14 version, second model), 50 patients follow a one compartment model with IV dosing and 50 patients follow a 2 compt model with extravascular input.

We assume they share V and Cl. The bioavailability is 50% (ilogit0).

 

You can share model parameters by defining these shard parameters (see graph in the model) and linking them to the V and Cl of both models.

 

I hope it helps. If something not clear or the question was different, please let me know.

best Regards

Serge

Attached Files

•  IV_ORAL_different_models.phxproj   975.48KB   359 downloads

[Igor Vostiar]

Dear Serge,

Thank you for for a prompt reply, this is exactly what I am looking for. The only problem I have at the moment is how to open the project file, my system is Build 6.3.0.395 and it has difficulties to open the project file..

[serge guzy]

Dear Serge,

Thank you for for a prompt reply, this is exactly what I am looking for. The only problem I have at the moment is how to open the project file, my system is Build 6.3.0.395 and it has difficulties to open the project file..

Here we go. I translated into13. please upgrade to 14 ASAP. The 13 version is really out dated and you should not use it.

Best Regards

Serge

Attached Files

•  version13_iv_oral_2_diff_models_shared_parameters.phxproj   753.75KB   317 downloads

[Simon Davis]

Hi Igor, also don't foget to use the search function; e.g. 'simultaneous' there are several related threads on here already;

 

http://www.certara.c...hl=simultaneous

 

http://www.certara.c...hl=simultaneous

 

http://www.certara.c...hl=simultaneous

 

http://www.certara.c...hl=simultaneous

 

 Simon