There was linked-in discussion about performing Tmax (a discrete variable) statistical comparison for a cross-over study data in Phoenix WinNonlin. There was response from a user: he indicated that go to NCA> Toolbox>Xover.

By following this routine you can perform a nonparametric analysis of Tmax for the parameters for the cross-over study. I have found an example in the EXAMPLES. I repeated the example (for 2 way comparison) and it worked fine. It provides the confidence intervals for the comparison of two formulations. I am wondering if it provides the intrasubject and intersubject variance information analogous to what one gets for bioequivalence of Cmax or AUC.

I think this Tmax comparison is limited to a 2 way cross-over study and will not work for a higher order comparison.....yes?

**Edited by Angus McLean, 16 May 2015 - 02:33 PM.**