We have preclinical species pharmacokinetic data(rat mice and dog) of compound X.We have performed PK modeling of all data set.
Results are
- Rat follow 2 comartmental model (model 11 in phoenix winNonlin)- best fit
- Mice follow 1 comartmental model (model 3 in phoenix winNonlin)- best fit
- Dog follow 1 comartmental model (model 4 in phoenix winNonlin)- best fit
Now the question is which model will consider for simulation in human for PK profile prediction??