Dear All,
In NLME, while doing population analysis, (single dose (5 mg) data, 10 subjects) the final model is copied, with all the fixed and random effects were accepted.
By checking the sim /pred.check box (changing from simple) in the copied model and using # of replicates as 10, with N iterations changed to 0, 10 replica were generated. Nothing was selected in Binning option. Adding a simulation table generated some more data (with time points mentioned in the sequence).
Is it the way pred check is done ?
What does the option " Pred. Corr" in the main tab mean ??
I would like to simulate for a new dose say for e.g., 10 mg instead of 5 mg. How would i do that by keeping the final model intact. Do i have to add another excel to the data object ?? Any example file would be helpful !!
thanks in advance..
Raghav
In NLME, while doing population analysis, (single dose (5 mg) data, 10 subjects) the final model is copied, with all the fixed and random effects were accepted.
By checking the sim /pred.check box (changing from simple) in the copied model and using # of replicates as 10, with N iterations changed to 0, 10 replica were generated. Nothing was selected in Binning option. Adding a simulation table generated some more data (with time points mentioned in the sequence).
Is it the way pred check is done ?
Yes but visual predictive checks will show in output only the predictions at the observed times (90% confidence bounds superimposed with observed data) . The add/sim table is an "add on" and it results in a simulation of different patients (different random numbers) where the link with the data is only through the dosing and covariate information.
What does the option " Pred. Corr" in the main tab mean ??
It should be a correction for the binning option as observed times across the population can be different (one patient t=3.3, other 3.3, other 3,etc..., difference between nominal and actual times or just differences across patients by design)
I would like to simulate for a new dose say for e.g., 10 mg instead of 5 mg. How would i do that by keeping the final model intact. Do i have to add another excel to the data object ?? Any example file would be helpful !!
You just replace the observed data set by a template one where you put only the dosing information. each id patient will show a different dosage regimen and/or different covariate setting.
In add/sim table you select the times of observations.
The vis pred simulation has no meaning in that case as you just do pure simulation. Only rawsim...csv output is the one that you should look at.
I am out of town. If not clear enough let me know and I will send you an example this week-end.
Best Regards
Serge