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Floating point error

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#1 johmak



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Posted 24 November 2015 - 10:54 AM



I have an issue with my Phoenix Winnonlin ASCII model. Here's my differential equations: 


DZ(1)= -KA*Z(1)

DZ(2)=KA*Z(2) - KEL*Z(2)

DZ(3)=Constant *( 1 - ( 0.954 *  IC50**Hill / ( (Z(2)/V*fu)**Hill + IC50**Hill ) ) ) - Constant*Z(3)


I get error message "Processing halted due to floating point error: INVALID NUMBER" when I use this hill parameter (temporary variable) and rational numbers such as 0.7 , 2.3 etc. There's also same error message when using simulation mode. Already I have resolved that simulation and parameter estimating work if I use whole number 0,1,2,3,4....


I have also other differential equations with exponent (used decimal numbers) but these work properly.


best regards



#2 Simon Davis

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Posted 07 December 2015 - 03:25 PM

Hi ? Johanna,


   I'm not sure I can answer your question without seeing your data or at least some subset of it, maybe parametising with dose and conc values standardised to a common unit would help e.g. if conc was ug/mL and dose was 10 mg then enter 10000ug.

  Also the WNL classic engine is old and particularly for custom models I think you will have more success with PML in the Phoenix model engine, have yout tried your model in that?



#3 geetjaan



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