Please note that Product Notification PHX032 has been issued for Phoenix 1.4 that affects NLME and Connect users only. It does not affect WinNonlin users. The Product Notification is also posted on the Certara Support website. This notification contains two defects:
PHOENIX CONNECT DEFECT (affects Phoenix Connect 1.4):
CDISC Data Preparer can produce incorrect Sample results with multiple Subject Identifiers (QC 15247/CRM 154491): The CDISC Data Preparer merges data from the DM (Demographics) and the PC (Pharmacokinetic Concentrations) domains using the columns mapped to the Subject Identifier mapping context. The resulting “Sample” dataset contains the merged DM and PC data. In Phoenix 1.4, if multiple columns were mapped as identifiers, the code did not properly compare all mapped columns when executing the merge. The only workaround in Phoenix 1.4 is to map a single column to the Subject Identifier mapping context, if one identifier is sufficient.
PHOENIX MODEL OBJECT DEFECT (affects Phoenix NLME 1.3):
Quantiles are computed incorrectly for prediction-correction VPC (QC 15573): In Phoenix 1.4, the quantiles of the original observation data are being determined before the original observation data is prediction-corrected. Therefore, the values are incorrectly reported as being identical before and after the correction. The incorrect output is in the Observations worksheet and in the VPC plot for the quantiles of the observed values (lines in red). There is no known workaround.