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Product Notification for PHX 1.4 (PN PHX032)

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#1 Linda Hughes

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Posted 09 March 2016 - 04:08 PM

Please note that Product Notification PHX032 has been issued for Phoenix 1.4 that affects NLME and Connect users only.  It does not affect WinNonlin users.  The Product Notification is also posted on the Certara Support website.  This notification contains two defects:


PHOENIX CONNECT DEFECT (affects Phoenix Connect 1.4):


CDISC Data Preparer can produce incorrect Sample results with multiple Subject Identifiers (QC 15247/CRM 154491):  The CDISC Data Preparer merges data from the DM (Demographics) and the PC (Pharmacokinetic Concentrations) domains using the columns mapped to the Subject Identifier mapping context. The resulting “Sample” dataset contains the merged DM and PC data.  In Phoenix 1.4, if multiple columns were mapped as identifiers, the code did not properly compare all mapped columns when executing the merge. The only workaround in Phoenix 1.4 is to map a single column to the Subject Identifier mapping context, if one identifier is sufficient.




Quantiles are computed incorrectly for prediction-correction VPC (QC 15573):  In Phoenix 1.4, the quantiles of the original observation data are being determined before the original observation data is prediction-corrected.  Therefore, the values are incorrectly reported as being identical before and after the correction.  The incorrect output is in the Observations worksheet and in the VPC plot for the quantiles of the observed values (lines in red).  There is no known workaround.


#2 Simon Davis

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Posted 14 March 2016 - 02:03 PM

If you're in Europe be aware that there is a one day (8am to 4pm) Roadshow 26 April, Basle and 28 April Cambridge UK, that will include demonstrations as well as the some presentations of interest; e.g.

2016 Software Roadmap
  • New features and functions for Phoenix
  • Conceptualization and benefits of a biosimulation model platform
  • Presenting and reporting PK, PD and Tox results to maximize impact
Leveraging Workflow Templates
  • Pre-clinical
  • Clinical
Case Studies: Creating a Pharmacometric Strategy
The Value Chain of Modeling

Automating Pivotal PK/PD Processes using Plug-ins
  • Interoperability with LIMS, allometric scaling algorithms, and CDISC submission systems
Introducing Certara University’s new e-learning platform and content

You can register through our website;

e.g https://www.certara....dshow-cambridge

US dates will be in May and early June;

Princeton, NJ – May 5, 2016
Durham (Raleigh), NC – May 12, 2016
San Diego, CA – May 17, 2016
Lincolnshire (Chicago), IL – May 19, 2016
Boston, MA – June 9, 2016


Edited by Simon Davis, 15 March 2016 - 03:31 PM.

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