Dear All,
I have a PK-PD model which runs fine without covariates.
When I add covariates, the following error occurs:
Error in Population:
'".\NLME7.exe"' is not recognized as an internal or external command,
operable program or batch file.
Model execution failed or cancelled
My covariates are in the PD model and are categorical. They are there to explain the effect that a co-medication has on the activity of a tumor killing drug:
I define them like this:
covariate(DRUG1())#categorical covariates
covariate(DRUG2())
stparm(kill0 = tvkill0*exp(effectDRUG1(DRUG1==1))*exp(effectDRUG2(DRUG2==1))*exp(nkill0)) #DRUG1 and DRUG2 as covariates of kill rate
fixef(tvkill0 = c(0,0.0002,))
fixef(effectDRUG1= c(0,1,)) #increase of kill rate due to drug1
fixef(effectDRUG2 = c(0,1,)) #increase of kill rate due to drug2
Then, I map the covariates"DRUG1" to a column with 0 and 1 respectively, where 0 is no co-medication and 1 is co-medication. I do the same for "DRUG2". I looked in the manual and on this forum and I think I am doing it right, but it clearly seems that I am missing something...
Can someone give me a hint, of what I may be doing wrong?
Best,
Joao