Dear All,
I have modeled the PK data of a compound and found that the covariates, weight (on V1 and V2 , model is 2 compartment) and creatinine clearance (on Clearance) have significant effect (decrease in OFV and other model diagnostics).
I have few questions on the simulation of exposures.
How do i simulate the exposures (AUC & Cmax) in subjects with low creatinine clearance, for e.g the average creatinine clearance in males and females is ~ 6.5 - 8 L/h with normal kidney function and as age increases the creatinine clearance decreases and the exposures may increase. How do i simulate the exposures in subjects with decrease renal function ?
Where do i find or how to get the individual estimates of clearance and volume of distribution and Ka ? do i have to use the table option for the same ?
Any help is appreciated.
Best regards,
Raghav