Hi,
I am studying the turnover of proteins, peptides and antibodies (Dr. Dan Weiner's textbook). There is an application about the turnover of hormone (PK30). A volunteer received a 40 ug/kg dose D of IgX (sc). The IgX concentrations were measured before and after the dose. WNL5 ASCII format was used to calculation PK parameters (V, ka, turn-over rate and Cl etc). Please see the attachment.
I am wondering if there is any other method to do PK turnover model besides WNL5 ASCII format. I tried Indirect response model (IR) and PKPD model. But it seems that these two models are for PD data.
Thank you!
LLLi