I am wondering if WinNonlin can perform non-parametric analysis to compare the median differences in Tmax between two periods.
The brief study design is as follows.
Period 1 (drug A) ---> washout ---> period 2 (drug A and
I want to calculate the median, interquartile range(IQR), median difference and its 90% CI and 95% CI.
Can I use linear mixed effect model to do this work?