Hi,
I am trying to use the bioequivalence wizard to generate GMRs/90% CI for a study with 4 PK assessments over the course of pregnancy. Dose was increased at the 3rd PK, but otherwise the treatments are the same and obviously there was no randomization/cross-over and the sequence is the same for everyone. I can make it work with the parallel design, but that's not quite right since the AUCs are not independent. Is there a way to change the set up in the cross-over set-up to allow me to do this with the same sequence and treatment for all subjects, but also account for the fact that the same subjects were sampled repeatedly?
Thanks,
Julie