I have a question that is not related to the WinNonlin software usage. But I still posted here and hope somebody can help me.
I am investigating the drug-drug interaction of a CYP3A4 inhibitor and compound A. Compound A is primarily metabolized by CYP3A4 inhibitor. One of the metabolites of A is M1. The metabolism of A is not very clear yet.
My results show that the inhibitor could increase the Cmax and AUCs of A. Surprisingly, the inhibitor could also increase the the Cmax and AUCs of M1 and slightly increase the ratio of M1 to A (Cmax and AUCs ratio). I am very confused by these results. What is the possible reasons that the inhibitor increase the exposure of both parent drug and its metabolites?
Thank you! Any input is appreciated!
Edited by LLLi, 02 November 2016 - 02:05 AM.