I have a question about the dosing setting in NCA.
Drug A was dosed 300 mg on Day 1 and 30 mg on Days 2 to 6. We collected the blood sample on Day 4 (pre-dose and several time points post-dose) for PK analysis. I assume that PK concentration is at steady state at that time points. How to set dose and tau in NCA? Or making the situation more complex, if drug A was dosed 150 mg twice on Day 1 and 30 mg on Days 2 to 6, how to set up the dose and tau?
Thank you very much for your help!